Biochemical parameters of blood and urine of rats at six-week administration of Nalbuphine

Given the widespread use in medicine of opioid analgesics, today it is extremely important to study morphofunctional changes various organs with prolonged exposure opioids. In modern scientific literature there are works which biochemical indicators blood at narcotic analgesics experiment covered. To parameters and urine long-term Nalbuphine an area research. The aim was detect some rats six-week administration therapeutic doses Nalbuphine. based on 40 white adult male weighing 180-260 g, were injected daily for six weeks injection 20 mg daily, intramuscularly doses. Daily diuresis creatinine content determined samples. total protein, creatinine, urea, calcium phosphorus glomerular filtration rate also by clearance endogenous creatinine. All statistical calculations performed using R Studio v.1.1.442 Commander v.2.4-4 software. results showed that affects reabsorption function kidney. two does not cause significant parameters, but established deviations may indicate first signs renal dysfunction. Further Nalbuphine, including end sixth week experiment, leads functions kidneys, as evidenced statistically rats. data can be used compare functional state kidneys caused its withdrawal other drugs combination It advisable morphological different times